GeroScience
Longitudinal changes in epigenetic measures over 2 years: methodological implications.
Rikuta Hamaya, Sidong Li, Brian H Chen, Alexandre C Pereira, Nichole Rigby, Haidong Zhu, Kerry L Ivey, Pamela M Rist, JoAnn E Manson, Yanbin Dong, Howard D Sesso
Published: 202510.1007/s11357-025-01990-2
Abstract
Epigenetic clocks are increasingly proposed as surrogate endpoints in aging trials, yet their short-term behavior in healthy older adults is not well characterized. We analyzed DNA methylation at baseline, year 1, and year 2 in 899 COSMOS-Blood parti…
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