Nα-p-tosyl-L-lysine chloromethyl ketone and Nα-p-tosyl-L-phenylalanine chloromethyl ketone are potent inhibitors of β-amyloid-induced lamin fragmentation.

Cellular toxicity induced by β-Amyloid (Aβ) peptide involves lamin A and lamin B fragmentation (LF),and inhibiting LF mitigates cytotoxicity; therefore, we aimed to identify novel inhibitors of Aβ-induced LF. We identified Nα-p-tosyl-L-lysine chlorom…

Preview only. Read the full abstract at the source