GeroScience
Early loss of astrocyte p38α MAPK reduces hippocampal neuroinflammation, enhances synaptic strength, and increases non-synaptic mitochondrial uncoupling in female mice during non-pathological aging.
Caleb S Bailey, John C Gant, Hilaree N Frazier, Josh M Morganti, Meggie C Coleman, Verda A Davis, Hemendra J Vekaria, Patrick G Sullivan, Christopher M Norris, Linda J Van Eldik, David J Braun
Published: 202510.1007/s11357-025-01948-4
Abstract
The p38 mitogen-activated protein kinase has a well-characterized role in modulation of inflammatory processes throughout the body. In the central nervous system, p38 is primarily studied within neurons and microglia, most commonly in the context of…
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