Molecular imaging and biology
First-in-Human Biodistribution and Dosimetry of [11C]Trimethoprim.
Anthony J Young, Robert K Doot, Joshua K Cho, Jonathan M Pham, Alvaro A Ordonez, Andres F Del Castillo, Tiffany L Dominguez, Supritha Dugyala, Erin K Schubert, Hsiaoju Lee, Austin R Pantel, Robert H Mach, David A Mankoff, Mark A Sellmyer
Published: 202510.1007/s11307-025-02064-7
Abstract
Trimethoprim (TMP) is a reversible inhibitor of the prokaryotic enzyme dihydrofolate reductase (DHFR) used for the treatment or prophylaxis of bacterial infections. [11C]trimethoprim ([11C]TMP) is a positron emission tomography (PET) imaging isotopol…
Preview only. Read the full abstract at the source