Journal of thrombosis and thrombolysis
Clinical, genetic, and nutritional determinants of INR: role of plasma warfarin and hydroxylated metabolite levels in anticoagulated Mexican patients.
Omar Rodríguez-Pérez, Juan Manuel López-Quijano, Cristian Jazmín Rodríguez-Pinal, Juan Manuel Vargas-Morales, Silvia Romano-Moreno, Rosa Del Carmen Milán-Segovia, Antonio Augusto Gordillo-Moscoso, Úrsula Fabiola Medina-Moreno, Susanna Edith Medellín-Garibay
Published: 202510.1007/s11239-025-03203-1
Abstract
Warfarin dosing guided by INR fails to account for pharmacokinetic/pharmacodynamic variability, leading to suboptimal outcomes; genetic and clinical factors, such as VKORC1 polymorphism and comorbidities, could refine dosing strategies and improve an…
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