Pharmaceutical researchProto-Oncogene Proteins c-aktLiposomesAnimalsMembrane ProteinsHumans
Co-encapsulation of an AKT Inhibitor Enhances the Tumor-cell Selectivity of STING Agonists in Co-delivery Liposomes.
Ziyu Ge, Qiang Zhang, Yuming Wang, Lin Miao, Xinqi Wang, Ni Fan, LiLi Duan, Yunfei Li, Xue-Jie Qi
Published: 202510.1007/s11095-025-03951-y
Abstract
OBJECTIVE: The therapeutic potential of STING agonists in cancer immunotherapy is hindered by poor tumor selectivity, resulting in systemic inflammation. Conventional targeted delivery strategies rely on cell-surface markers, which inadequately disti…
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