Pharmaceutical researchSolubilityAnimalsHumansCaco-2 CellsPolyglutamic Acid
Enhancing Cannabidiol Apparent Solubility and Oral Delivery: Self-assembled Nanomicelles of Amphiphilic Block Copolymer with γ-Polyglutamic Acid-grafted Cholesterol.
Rui Li, Wenhui Ruan, Liyan Lu, Zhijuan Wu, Rui Hao, Yingli Wang, Jue Chen
Published: 202510.1007/s11095-025-03924-1
Abstract
PURPOSE: Cannabidiol (CBD) exhibits antiepileptic, anticonvulsant, and anticancer effects. However, its clinical value is limited by poor oral absorption, low water solubility, and poor stability. Therefore, this study aimed to prepare a novel nanomi…
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