Neurochemical researchAnimalsPilocarpineMembrane GlycoproteinsReceptorsImmunologic
A Novel H2S Donor Suppresses Pilocarpine-Induced Seizures Through TREM2 Signaling.
Yan He, Xiao Wang, Yanqi Wu, Honghao Xu, Xutao Wang, TianTian Wang, Lian Liu, Shuisheng Lei, Xiaoqin Zhu
Published: 202510.1007/s11064-025-04602-9
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) located on microglial membranes and its downstream PI3K/PKB signaling pathway are involved in epilepsy. We have synthesized a novel carbazole-based H2S donor (HS-D2023) which was synthesized fr…
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