TLRs/PI3K/AKT1B Signaling Pathway Is Involved in Modulation of Neuroinflammation in the Rat Hippocampus by Alpha-pinene in Morphine-dependent and Withdrawing Rats.

Toll-like receptors (TLRs) in the brain significantly contribute to various central nervous system (CNS) disorders, including addiction. Morphine's interaction with TLR4 contributes to dependence and withdrawal. Alpha-pinene, a monoterpene with anti-…

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