Neurochemical researchAnimalsPentylenetetrazoleHippocampusPyrrolidinonesMice
Brivaracetam and Topiramate Co-Therapy Attenuates Seizure Progression, Neuroinflammation, and Hippocampal Pathology in Chronic Pentylenetetrazole-Kindled Mice.
Khaled Ahmed Saghir, Zohabia Rehman, Nosheen Malik, Waseem Ashraf, Syed Muhammad Muneeb Anjum, Rana Muhammad Zahid Mushtaq, Faleh Alqahtani, Imran Imran
Published: 202510.1007/s11064-025-04571-z
Abstract
Rational polytherapy is increasingly gaining attention when monotherapy fails to control seizures. Accordingly, the current study investigated the effects of topiramate and brivaracetam, administered individually (10 mg/kg each) or combined, on seizu…
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