Molecular biology reportsHumansAdenosine TriphosphateCell ProliferationLactic AcidMonocarboxylic Acid Transporters
Deguelin suppresses Nalm6 leukemia cell proliferation through lactate accumulation and ATP depletion.
Xingyan Luo, Kaiyu Feng, Ketian Zhao, Ting Zhang, Juncheng Qiu, Huijie Guo, Yantang Wang, Shuxia Yang, Chunfen Mo, Yang Liu
Published: 202510.1007/s11033-025-11403-4
Abstract
BACKGROUND: Acute lymphoblastic leukemia (ALL) is characterized by metabolic reprogramming, including elevated glycolysis and lactate production. Monocarboxylate transporter 1 (MCT1/SLC16A1) is frequently overexpressed in ALL, sustaining glycolytic f…
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