Molecular biology reportsHumansMaleProstatic NeoplasmsTranscriptional Regulator ERGTumor Suppressor Protein p53
Uncovering the role of ETS2 in prostate cancer pathogenesis: relationship with p53 and ERG.
Laura Segalés, Nuria Juanpere, Marta Lorenzo, Beatriz Casado, Sílvia de Muga, Marta Salido, Alejo Rodriguez-Vida, Lluís Fumadó, Lluís Cechinni, Joaquim Bellmunt, Silvia Hernández-Llodrà
Published: 202610.1007/s11033-025-11258-9
Abstract
BACKGROUND: ETS2 expression in prostate cancer (PCa) shows variability, with overexpression and loss reported. ETS2 can be dysregulated through proteasomal degradation, but p53 missense mutants may stabilize ETS2 by preventing this process. TP53 muta…
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