Molecular and cellular biochemistry
Ivermectin modulates macrophage activity and enhances bacterial clearance in Pseudomonas aeruginosa acute pneumonia.
Thiago Caetano Andrade Belo, Natália Cristina de Melo Santos, Leonardo Pereira de Araújo, Ana Sofia Martelli Chaib Saliba, Severino Matias de Alencar, Graziela Domingues de Almeida Lima, Rômulo Dias Novaes, Flávio Protásio Veras, Giovane Galdino de Souza, Patrícia Paiva Corsetti, Leonardo Augusto de Almeida
Published: 202510.1007/s11010-025-05419-4
Abstract
The TLR4 receptor, together with the MD-2 co-receptor, is essential for macrophage recognition of LPS from Gram-negative bacteria such as Pseudomonas aeruginosa. Although ivermectin improves survival following LPS challenge in mice, its immunological…
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