Journal of pharmacokinetics and pharmacodynamicsHumansNeoplasmsImmunoconjugatesKineticsBiological Transport
A QSP PDE model of ADC transport and kinetics in a growing or shrinking tumor.
David S Ross, Antonio Cabal
Published: 202510.1007/s10928-025-10001-y
Abstract
When a tumor is treated with an antibody-drug conjugate (ADC) complex biochemistry occurs in a domain-the tumor-whose size and structure are changing. Some parts of the tumor may be growing because tumor cells proliferate. Other parts may be stagnant…
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