Journal of computer-aided molecular designSurvivinQuantitative Structure-Activity RelationshipHumansMolecular Docking SimulationPyridines
Synthesis of 4,6-diphenyl-3-cyanopyridine derivatives based on 3D-QSAR: unveiling their potential as survivin inhibitors.
JiaHao Lu, ChenHao Zhao, YingQI Qiu, Li-Qun Shen, Hua Zhu, Miao Zhang
Published: 202610.1007/s10822-025-00737-7
Abstract
Survivin, a multifunctional regulator of mitosis and apoptosis, plays a central role in cancer progression and therapy resistance, making it an attractive target for anticancer drug development. In this study, a series of 4,6-diphenyl-3-cyanopyridine…
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