Journal of computer-aided molecular designDeep LearningHumansProgrammed Cell Death 1 ReceptorLymphocyte Activation Gene 3 ProteinMolecular Dynamics Simulation
Deep learning-guided rational engineering of synergistic PD-1 and LAG-3 blockade for enhanced tumor immunomodulation.
Shanza Mazhar, Taskeen Koser, Rana Rehan Khalid
Published: 202510.1007/s10822-025-00702-4
Abstract
Evolution has optimized proteins over time by the incorporation of precise and context-specific amino acid substitutions adapted to structural and functional demands. We have reconceptualized this principle using deep learning to engineer monoclonal…
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