Inflammopharmacology
Trans-Chalcone alleviates overt pain-like behavior by targeting the activation of nociceptive neuron TRPV1 and TRPA1 channels.
Maiara Piva, Kelly M Yaekashi, Thais G O Pereira, Mariana M Bertozzi, Felipe A Pinho-Ribeiro, Cássia Calixto-Campos, Doumit Camilios-Neto, Sergio M Borghi, Ana C Zarpelon-Schutz, Victor Fattori, Rubia Casagrande, Waldiceu A Verri
Published: 202610.1007/s10787-025-02099-w
Abstract
OBJECTIVE: Trans-Chalcone (TC) is an anti-inflammatory flavonoid that reduces hyperalgesia by targeting nuclear factor κB and inflammasome in gout arthritis model. However, a direct modulation of nociceptors by TC has never been investigated, which w…
Preview only. Read the full abstract at the source