Inflammation
Inhibition of the JAK/STAT Signaling Pathway Suggests a Protective Effect against Acantholysis in Pemphigus.
Farzan Solimani, Julia Holstein, Katharina Meier, Luz Maria Cano Rochin, Alberto Mesas-Fernandez, Yun-Fei Jiang, Maria A Feoktistova, Morna F Schmidt, Amir S Yazdi, Franz Joachim Hilke, Kamran Ghoreschi
Published: 202610.1007/s10753-025-02417-y
Abstract
Pemphigus is a severe autoimmune blistering disorder of skin and mucosa, which is elicited by gG autoantibodies targeting desmosomal components such as desmoglein 3 (Dsg3). Keratinocytes lose cytoarchitectural stability and reciprocal adhesion in a p…
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