Inflammation
Programmed death-ligand 1 (PD-L1) Modulates Chemokine Production Via the TLR4/TRAF6 Signaling Axis During LPS + IFN-γ-Induced Endotoxemia-mimicked Sepsis.
Mu Yuan, Tong Jin, Luoquan Ao, Junyu Zhu, Weijun Wan, Quan Chen, Yuchuan Yuan, Qing Zhao, Xiang Xu, Lixing Tian
Published: 202610.1007/s10753-025-02394-2
Abstract
As a pivotal immune checkpoint molecule, programmed death-ligand 1 (PD-L1) is anchored primarily on the membrane surface of immune cells, where it exerts immunosuppressive effects, thereby facilitating tumor immune evasion. Macrophages, which serve a…
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