Inflammation
Intestinal Sclerostin Deficiency Links Gut Dysbiosis to Altered Serotonin Homeostasis in Axial Spondyloarthritis.
Daniele Mauro, Anne-Sophie Bergot, Giuliana Guggino, Alessia Salzillo, Giulio Forte, Antonio Ciancio, Aroldo Rizzo, Stefania Raimondo, Luca Lentini, Saviana Gandolfo, Soohyun P Kim, Chi Wong, Barbara De Marino, Simon Milling, Riccardo Alessandro
Published: 202610.1007/s10753-025-02393-3
Abstract
BACKGROUND: Sclerostin regulates bone formation via Wnt/β-catenin signaling inhibition and contributes to intestinal epithelial homeostasis. Circulating sclerostin levels are reduced in axial spondyloarthritis (axSpA) and correlate with structural da…
Preview only. Read the full abstract at the source