Inflammation
HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated Encephalopathy.
Meng Cai, Hua Shao, Shan Xu, He Wang, Meng-Jie Yang, Tong Zhu, Jiang Chen, Gui-Zhou Li, Shuai-Fei Lu, Yan-Yu Zang, Mu-Huo Ji, Jin-Chun Shen, Min Jia, Jian-Jun Yang
Published: 202610.1007/s10753-025-02360-y
Abstract
Microglial pyroptosis-mediated neuroinflammation emerges as a critical pathogenic mechanism underlying sepsis-associated encephalopathy (SAE). Epigenetic modifications, especially histone acetylation states, exert fundamental regulatory effects on mi…
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