Journal of molecular histologyHumansErbB ReceptorsProto-Oncogene Proteins c-aktTriple Negative Breast NeoplasmsSesquiterpenes
Study on the mechanism of costunolide inhibiting triple-negative breast cancer by EGFR ubiquitination and degradation to suppress the ERK/AKT signaling pathway.
Ying Li, Junjie Mu, Qiuxiong Chen, Qian Ming, Chaohong Zhu, Yujie Xiao, Baoli Qiu, Xue Zhang, Baoshun Zhang, Xian Yang
Published: 202510.1007/s10735-025-10604-2
Abstract
Costunolide (COS) is a bioactive sesquiterpene lactone compound extracted from Aucklandia lappa, known for its anticancer, anti-inflammatory, and antioxidant properties, aligning with the traditional Chinese medicine theory of "clearing heat and disp…
Preview only. Read the full abstract at the source