Biochemical genetics
Tanshinone I Represses Ferroptosis to Protect Against Steroid-Induced Osteonecrosis of the Femoral Head by Activating the Nrf2/SLC7A11 Axis.
Liangyu Lu, Miaomiao Zhou, Xiaolong Zhang, Xiabing Qin
Published: 202510.1007/s10528-025-11247-4
Abstract
We sought to explore how Tanshinone I (TsI) mediates ferroptosis in femur tissue in a rat model of steroid-induced osteonecrosis of the femoral head (SIONFH). Rats were given lipopolysaccharide and methylprednisolone to develop a rat model of SIONFH…
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