BiogerontologyAnimalsMaleGhrelinLiverAnti-Bacterial Agents
Antibiotic exposure alters the LEAP-2/ghrelin axis and anti-inflammatory tone in aged male rat liver and adipose tissue.
Rabia Ilgin, Oya Sayin, Mehmet Ates, Erhan Caner Akkaya, Ferda Hosgorler
Published: 202510.1007/s10522-025-10368-y
Abstract
Liver-expressed antimicrobial peptide-2 (LEAP-2), the endogenous antagonist of the ghrelin receptor (GHSR1a), counterbalances ghrelin in an energy- and inflammation-dependent manner. Aging is accompanied by endocrine and immunometabolic shifts that m…
Preview only. Read the full abstract at the source