Bulletin of experimental biology and medicineAnimalsSpike GlycoproteinCoronavirusVaccinia virusMice
Effect of the C12L, A35R, A40R, and A41L Genes of MVA Vector on the Immunogenicity of Recombinant MVA Expressing the SARS-CoV-2 Spike Protein.
O V Orlova, D V Glazkova, R R Mintaev, G M Tsyganova, N F Brazgun, G A Shipulin, E V Bogoslovskaya
Published: 202510.1007/s10517-026-06561-9
Abstract
Modified vaccinia virus Ankara (MVA) is a highly attenuated strain of vaccinia virus widely used as a recombinant vector in vaccine development. Several studies have shown that deletion of the C12L, A35R, A40R, and A41L genes from the MVA genome can…
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