Apoptosis : an international journal on programmed cell deathHumansColorectal NeoplasmsCetuximabSuccinic AcidTumor-Associated Macrophages
Succinate-mediated SUCNR1 activation in tumor-associated macrophages promotes M2 polarization and cetuximab resistance in colorectal cancer: in vitro and in vivo insights.
Shaofei Chen, Zhiyong Wang, Ping Sun, Yang Liu
Published: 202610.1007/s10495-025-02239-1
Abstract
Colorectal cancer (CRC) ranks among the most prevalent and lethal malignancies globally, with Cetuximab (CTx) resistance being a significant hurdle in its treatment. To uncover the underlying mechanisms, this study recruited 27 metastatic CRC patient…
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