Neurosurgical reviewHumansB7-H1 AntigenBrain NeoplasmsCombined Modality TherapyImmune Checkpoint Inhibitors
The clinical outcomes of combined stereotactic radiosurgery with PD-1/PD-L1 inhibitors in patients with metastatic brain tumors: a systematic review and meta-analysis on the safety and efficacy.
Muhammad Hussain Ahmadvand, Mohammad Amin Habibi, Mohammad Sina Mirjani, Amirmohammad Bahri, Fateme Aghaei, Amirmahdi Foroughi, Yalda Ghazizadeh, Mohammad Shahir Eftekhar, Hossein Gandomkar, Pouria Delbari, Ibrahim Mohammadzadeh, Bardia Hajikarimloo, Salem M Tos, Milad Shafizadeh, Jason P Sheehan
Published: 202510.1007/s10143-025-03909-z
Abstract
Brain metastases (BM) pose a significant challenge due to limited treatment options and poor prognosis. Combining PD-1/PD-L1 inhibitors with stereotactic radiosurgery (SRS) may enhance tumor control through synergistic effects. This study assessed th…
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