Functional & integrative genomicsHumansMethylenetetrahydrofolate Reductase (NADPH2)PolymorphismSingle NucleotideNucleic Acid Amplification Techniques
The application of RPA-PfAgo technology combined with multidimensional data analysis in the rapid detection of the MTHFR A1298C polymorphism.
Yaqun Liu, Lianghui Chen, Xuanyi Zheng, Peikui Yang, Jinkun Han, Jiayi Huang, Yanling Shen, Xiaotong Cai, Miaofen Fang, Yicun Chen, Chengsong Xie, Min Lin, Yuzhong Zheng
Published: 202510.1007/s10142-025-01800-0
Abstract
This study presents a novel approach that integrates recombinase polymerase amplification (RPA) with PfAgo protein technology for the rapid and precise detection of the MTHFR A1298C polymorphism. Although traditional genotyping methods are effective,…
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