Functional & integrative genomicsCarcinomaHepatocellularLiver NeoplasmsHumansRNA-Binding Proteins
Hypoxia-Induced m6A modification via YTHDF2 stabilizes PFKL to fuel MDSC Glycolysis and hepatocellular carcinoma progression.
Ziqi Guo, Yuying Huang, Xiaoling Dong, Linyan Shen, Fuguo Yan, Cheng Yang
Published: 202510.1007/s10142-025-01743-6
Abstract
Hepatocellular carcinoma (HCC) progression is driven by cancer stem cells (CSCs) with self-renewal and immune evasion capacities. Here, we identify a novel HIF-1α/YTHDF2/PFKL axis that orchestrates metabolic reprogramming in myeloid-derived suppresso…
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