Functional & integrative genomicsArtificial IntelligenceHumansGene EditingCRISPR-Cas SystemsRNA
Artificial intelligence-driven epigenetic CRISPR therapeutics: a structured multi-domain meta-analysis of therapeutic efficacy, off-target prediction, and gRNA optimization.
Mustafa Kemal Basarali, Amin Daemi, Ruhiyya Guliyeva Tahiraga, Gülüzar Özbolat, Mohammad Hosseini Hooshiar, Malihe Sagheb Ray Shirazi, Yusuf Döğüş
Published: 202510.1007/s10142-025-01725-8
Abstract
CRISPR-based epigenetic editing enables reversible regulation of gene expression without permanent DNA modification. The integration of artificial intelligence (AI) enhances guide RNA (gRNA) design, off-target prediction, and delivery optimization. W…
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