Functional & integrative genomicsHumansGlioblastomaProto-Oncogene Proteins c-aktDrug ResistanceNeoplasm
Hypoxia-induced S100A10 promotes glioblastoma malignancy and chemoresistance by activating PI3K-AKT signaling pathway.
Qingqing Yang, Yunlan Xi, Xuewei Huang, Wenzhe An, Cuiyun Sun, Qian Wang, Dan Hua, Wenjun Luo, Cuijuan Shi, Hongli Pan, Zhendong Jiang, Bingkun Wang, Xuebing Li, Shizhu Yu, Xuexia Zhou
Published: 202510.1007/s10142-025-01693-z
Abstract
Glioblastoma (GBM) is the most frequent and lethal subtype of glioma that leads to unsatisfactory clinical outcomes. Hypoxia-induced chemoresistance exacerbates therapy. S100 calcium-binding protein A10 (S100A10) plays a crucial role in the oncogenes…
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