European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
In vivo evolution of resistance to novel β-lactam/β-lactamase inhibitor combinations through overproduction of the horizontally acquired extended-spectrum AmpC β-lactamase FOX-14 and porin disruption in Serratia marcescens.
Salud Rodríguez-Pallares, Lucía González-Pinto, María Tarriño-León, Pablo Aja-Macaya, Lucía Sánchez-Peña, Miriam Moscoso, Gloria Pérez-Rodríguez, Tania Blanco-Martín, Alejandro Beceiro, Germán Bou, Jorge Arca-Suárez
Published: 202510.1007/s10096-025-05352-w
Abstract
We investigated the genetic and biochemical determinants that reduce the activity of several β-lactam/β-lactamase inhibitor combinations against Serratia marcescens clinical isolates after carbapenem exposure. We analyzed paired clinical S. marcescen…
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