Low molecular weight porcine placenta peptide (Placenderm®) as a functional ingredient for hair health: evidence from in vitro and in vivo studies.

Hair loss, marked by thinning hair, reduced density, and increased scalp visibility, is a growing concern. The hair growth cycle is regulated by a dynamic balance between stimulatory growth and inhibitory cytokines. While placenta extracts have demonstrated regenerative, anti-aging, and immunomodulatory effects, their potential role in promoting hair follicle regeneration remains largely unexplored. This study investigated the effects of low molecular weight porcine placenta peptides (Placenderm®) on hair growth. In hDPCs, Placenderm® enhanced cell proliferation and modulated gene expression by upregulating growth-promoting markers and downregulating inhibitory markers. In C57BL/6 mice model, administration of Placenderm® accelerated hair regrowth, prolonged the anagen phase, and led to notable improvements in hair follicle number, size, thickness, and luster. These findings suggest that Placenderm® promotes follicular regeneration by restoring the balance between growth factors and inhibitory cytokines, highlighting its potential as a safe and effective functional food ingredient for hair health applications. Supplementary Information: The online version contains supplementary material available at 10.1007/s10068-025-01996-8.