Disruption of the intramolecular interaction between human lung cancer-related EGFR kinase domain and carboxy-terminal tail by intra-Tyr1016 phosphorylation or extra-peptidic competitors.

CONTEXT: Human epidermal growth factor receptor (EGFR) controls many key signaling pathways associated with cell growth/survival and is a well-established druggable target of lung cancer. Previous studies have primarily focused on the extracellular l…

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