Quantum-topological simulation of Berry phase-induced fentanyl-μ-opioid receptor dissociation via terahertz vortex fields.

CONTEXT: Fentanyl's sub-nanomolar affinity and ultra-slow dissociation from the μ-opioid receptor (μOR) limit the efficacy of pharmacological antagonists like naloxone in acute overdose. We propose a non-pharmacological strategy in which structured t…

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