Molecular genetics and genomics : MGGHumansTemozolomideGlioblastomaAnimalsDrug Resistance
RBM7 suppresses mitochondrial dysfunction and ferroptosis by destabilizing FBXL16 mRNA to enhance Temozolomide resistance in glioblastoma.
Nan Liu, YeTing Cui, Juan Li, SuMei Li, YanYang Tu, JunLi Huo, TongCun Zhang, HaiNing Zhen
Published: 202510.1007/s00438-025-02313-y
Abstract
OBJECTIVE: Temozolomide (TMZ) resistance is a major cause of treatment failure in glioblastoma (GBM). This study investigates the role and mechanism of the RNA-binding protein RNA-binding motif protein 7 (RBM7) and F-box and leucine-rich repeat prote…
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