European journal of pediatricsHumansInfantNewbornHypoxia-IschemiaBrain
Antibiotic use in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia: time to rethink universal empirical treatment.
Domenico Umberto De Rose, Fiammetta Piersigilli, Cinzia Auriti, Francesca Campi, Venere Cortazzo, An Samaey, Katherine Carkeek, Ludovica Martini, Chiara Maddaloni, Alessandra Santisi, Sara Ronci, Giulia Iacona, Iliana Bersani, Immacolata Savarese, Olivier Danhaive
Published: 202510.1007/s00431-025-06652-1
Abstract
Neonatal hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) can alter the immune system and may present symptoms similar to sepsis. This has led to widespread use of empirical antibiotics, despite limited evidence that su…
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