Histochemistry and cell biologyActinsAnimalsCell NucleusSerineHumans
The O-GlcNAcylation of β-actin Ser199 controls nuclear speckle localization and is dysregulated in diabetes.
Yoshihiro Akimoto, Yuri Miura, Akihiko Kudo, Toshiyuki Fukutomi, Tomio Arai, Yuko Chiba, Shinya Kaname, Kunimasa Yan, Gerald W Hart
Published: 202510.1007/s00418-025-02429-7
Abstract
Actin is a pivotal cytoskeletal protein that also regulates chromatin remodeling, transcription, and RNA processing within the nucleus. These nuclear functions are regulated by post-translational modifications (PTMs), but the roles of specific PTMs o…
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