Acta neuropathologicaHumansLewy Body DiseaseMaleReelin ProteinFemale
Spatially resolved molecular signatures of Lewy body dementia.
Yunjung Jin, Kai Chen, Alexander Q Wixom, Zonghua Li, Shunsuke Koga, Hiroaki Sekiya, Gisela Xhafkollari, Monica Castanedes-Casey, Hannah Santhakumar, Axel D Meneses, Abigail J Neff, Guojun Bu, Michael G Heckman, Yuanhang Liu, Owen A Ross
Published: 202610.1007/s00401-026-02981-z
Abstract
Lewy body dementia (LBD), encompassing dementia with Lewy bodies and Parkinson's disease dementia, is neuropathologically defined by neuronal accumulation of α-synuclein encoded by the SNCA gene. Genetic risk factors strongly influence LBD susceptibi…
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