Acta neuropathologicaMultiple System AtrophyAnimalsFerroptosisHumansalpha-Synuclein
α-synuclein triggers NCOA4-FTH1-mediated ferroptosis of oligodendrocyte in multiple system atrophy.
Zhenwei Yu, Ehsan Arkin, Yang Li, Marie-Hélène Canron, Marie-Laure Arotcarena, Hugo Jadot, Elio Balpe, Yue Huang, Tao Feng, Wassilios G Meissner, Jing Zhang
Published: 202610.1007/s00401-026-02978-8
Abstract
Multiple system atrophy (MSA) is a fatal neurodegenerative synucleinopathy characterized by the accumulation of α-synuclein in oligodendrocytes, forming glial cytoplasmic inclusions. Although iron dysregulation and ferroptosis, an iron-dependent form…
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