Basic research in cardiologyAnimalsDoxorubicinLipoproteinsHDLFemale
Dysfunctional high-density lipoprotein particles are associated with cardiac alterations in cancer patients and tumor-bearing mice receiving doxorubicin.
Carmelita Abrahams, Wanzhu Zhang, Nonhlakanipho Sangweni, Vitaris Kodogo, Nkanyiso Hadebe, Emmy Okello, Rabia Johnson, Nicholas J Woudberg, Karen Sliwa, Sandrine Lecour
Published: 202610.1007/s00395-025-01149-2
Abstract
Cancer patients receiving doxorubicin (DOX) chemotherapy are at high risk of developing cardiac alterations, but the mechanisms remain elusive. Both breast cancer and DOX therapy are associated with dyslipidemia. We aimed to investigate whether chang…
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