Cancer chemotherapy and pharmacologyHumansHand-Foot SyndromeCapecitabineFemaleMiddle Aged
Analysis of intercellular lipids in the stratum corneum of patients with capecitabine-induced hand-foot syndrome: comparison with the stratum corneum of healthy individuals.
Tomonobu Uchino, Michiaki Nakajo, Ichiro Hatta, Ikumi Suzuki, Mayuko Okada, Rikuto Terada, Yasunori Miyazaki, Misa Osawa, Keisei Taku, Tasuku Yokoyama, Daiki Tsuji, Yoshiyuki Kagawa
Published: 202610.1007/s00280-025-04842-0
Abstract
PURPOSE: Capecitabine (CAP) side effect, a prodrug of 5-fluorouracil (5-FU), is hand-foot syndrome (HFS), a localized skin disorder of the hands and feet that is believed to induce a decrease in skin barrier function. Stratum corneum (SC) lipids play…
Preview only. Read the full abstract at the source