Association of IL12RB2, RORC, and class II HLA polymorphisms with severe erythema multiforme of regorafenib in Japanese patients with colorectal cancer.

PURPOSE: The anticancer drug regorafenib can induce erythema multiforme (EM), an immune-mediated cutaneous and mucosal hypersensitivity reaction. We prospectively analyzed regorafenib in patients with metastatic colorectal cancer (mCRC) and found tha…

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