Cancer chemotherapy and pharmacologyHumansFemaleFluorouracilAgedDihydrouracil Dehydrogenase (NADP)
Severe toxicity following genotype-guided reduced 5-FU dose in a heterozygous DPYD c.2846A>T carrier with stage III anal carcinoma: A case report.
Madeline L Norris, David L DeRemer, Julio D Duarte, George P Kim, Thomas J George
Published: 202510.1007/s00280-025-04833-1
Abstract
BACKGROUND: Fluoropyrimidines (e.g., 5-fluorouracil, capecitabine) are antineoplastic agents commonly used in the setting of gastrointestinal cancer. Dihydropyridine dehydrogenase (DPD), encoded by the DPYD gene, is the enzyme responsible for up to 8…
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