European journal of nuclear medicine and molecular imaging
Brain metabolic connectivity in ALS due to C9ORF72 hexanucleotide expansion: a [18F]FDG-PET study.
Antonio Canosa, Stefano Callegaro, Umberto Manera, Rosario Vasta, Sara Cabras, Francesca Di Pede, Filippo De Mattei, Francesca Palumbo, Barbara Iazzolino, Anastasia Dei Giudici, Enrico Matteoni, Grazia Zocco, Emilio Minerva, Alessandra Maccabeo, Giorgio Pellegrino
Published: 202510.1007/s00259-025-07705-1
Abstract
PURPOSE: Our aim was to investigate brain metabolic connectivity, as assessed via [18F]FDG-PET, in ALS patients carrying the C9ORF72 expansion (C9-ALS). METHODS: We compared brain metabolism of C9-ALS and patients without mutations of the main ALS-re…
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