European journal of nuclear medicine and molecular imaging
Preclinical development of [18F]TAAR1-2203 as a PET radioligand for imaging TAAR1 expression and receptor occupancy.
Achi Haider, Zhiwei Xiao, Jiahui Chen, Stefanie K Pfister, Xin Zhou, Yinlong Li, Ahmad Chaudhary, Chunyu Zhao, Jian Rong, Axel Paehler, Susanne Mohr, Roger D Norcross, Michael Honer, Linjing Mu, Luca Gobbi
Published: 202510.1007/s00259-025-07564-w
Abstract
PURPOSE: Trace amine-associated receptor 1 (TAAR1) is an emerging therapeutic target with various implications in neuropsychiatric and metabolic disorders. However, the absence of a suitable positron emission tomography (PET) radioligand has preclude…
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