Pediatric cardiology
Nicorandil Attenuates Global Myocardial Ischemia-Reperfusion Injury and Systemic Inflammation Through Inhibition of TLR-4 Signaling in a Neonatal Piglet Model of Cardiopulmonary Bypass and Cardioplegic Arrest.
Yun-Wen Peng, Alvaro Rojas-Pena, Bailey Schneider, John Toomasian, Lise Tchouta, Matthew Johnson, Hayes McKenzie, John R Charpie
Published: 202510.1007/s00246-025-04125-8
Abstract
Pediatric cardiac surgery with cardiopulmonary bypass (CPB) and cardioplegic arrest is associated with global myocardial ischemia-reperfusion (IR) injury, leukocyte activation, and a systemic inflammatory response that contributes to early postoperat…
Preview only. Read the full abstract at the source