Psychopharmacology
Chronic delivery of buprenorphine during abstinence decreases incubation of heroin seeking and neuronal activation in medial prefrontal cortex and striatum in male and female rats.
Jennifer M Bossert, Kiera E Caldwell, Hannah Bonbrest, Rohan Patil, Mona S Pishgar, Rajtarun Madangopal, Huiling Wang, Yavin Shaham
Published: 202510.1007/s00213-025-06971-z
Abstract
RATIONALE AND OBJECTIVE: Buprenorphine is an FDA-approved medication for opioid addiction, but the brain regions underlying its therapeutic effects remain unknown. We previously found that chronic buprenorphine treatment decreases several relapse-rel…
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