Psychopharmacology
Effects of TPA023B, an α2/3/5GABAA subtype-selective partial allosteric modulator, on fentanyl-induced respiratory depression in male rats: comparison with the non-selective benzodiazepine midazolam.
Loc M Pham, Andria B Nanney, Jordan Hasting, Daniela Rüedi-Bettschen, Kevin B Freeman, James K Rowlett
Published: 202510.1007/s00213-025-06945-1
Abstract
RATIONALE: Opioid-related overdose deaths involving benzodiazepines have increased in recent years, and prior studies have reported that clinically used benzodiazepines can enhance the respiratory-depressant effects of mu opioid receptor (MOR) agonis…
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