Psychopharmacology
Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effects.
Kai Yao, Johan H Thygesen, Siobhan K Lock, Antonio F Pardiñas, Antonia L Pritchard, Israa Elbashir, Abdullah Lodhi, Zain-Ul-Abideen Ahmad, Michael C O'Donovan, Michael J Owen, James T R Walters, David St Clair, Nick Bass, Andrew McQuillin
Published: 202510.1007/s00213-025-06912-w
Abstract
RATIONALE: Antipsychotic medications are the first-line treatment for schizophrenia. Around 40% of people who are treated with antipsychotics could develop extrapyramidal side-effects (EPSE) including: (1) Dyskinesia, (2) Parkinsonism, (3) Akathisia,…
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